KEGG   Homo sapiens (human): 2868
Entry
2868              CDS       T01001                                 
Symbol
GRK4, GPRK2L, GPRK4, GRK4a, IT11
Name
(RefSeq) G protein-coupled receptor kinase 4
  KO
K08291  G protein-coupled receptor kinase [EC:2.7.11.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    2868 (GRK4)
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    2868 (GRK4)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2868 (GRK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    2868 (GRK4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.16  G-protein-coupled receptor kinase
     2868 (GRK4)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   2868 (GRK4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RGS Kinase-like Pkinase_fungal ABC1
Other DBs
NCBI-GeneID: 2868
NCBI-ProteinID: NP_892027
OMIM: 137026
HGNC: 4543
Ensembl: ENSG00000125388
UniProt: P32298
Structure
Position
4:2963571..3040760
AA seq 578 aa
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK
NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
NT seq 1737 nt   +upstreamnt  +downstreamnt
atggagctcgagaacatcgtggccaactcgctgctgctgaaagcgcgtcaaggaggatat
ggcaaaaaaagtggtcgtagtaaaaaatggaaggagatactgacactgcctcctgtcagc
cagtgcagtgagcttagacattccattgaaaaggattatagcagtctttgtgacaagcaa
ccgataggaagacgtctcttcaggcagttctgtgataccaaacccactctaaagaggcac
attgaattcttggatgcagtggcagaatatgaagttgccgatgatgaggaccgaagtgat
tgtggactgtcaatcttagatagattcttcaatgataagttggcagcccctttaccagaa
atacctccagatgttgtgacagaatgtagattgggactgaaggaggagaacccttccaaa
aaagcctttgaggaatgtactagagttgcccataactacctaagaggggaaccatttgaa
gaataccaagaaagctcatatttttctcagtttttacaatggaaatggctggaaaggcaa
cccgtaacaaagaacacatttagacattacagagttctaggaaaaggcggatttggagag
gtttgcgcctgtcaagtgcgagccacaggaaaaatgtatgcctgcaaaaagctacaaaaa
aaaagaataaagaagaggaaaggtgaagctatggctctaaatgagaaaagaattctggag
aaagtgcaaagtagattcgtagttagtttagcctacgcttatgaaaccaaagatgccttg
tgcttggtgctcaccattatgaatggaggggatttgaagtttcacatttacaacctgggc
aatcccggctttgatgagcagagagccgttttctatgctgcagagctgtgttgcggcttg
gaagatttacagagggaaagaattgtatacagagacttgaagcctgagaatattctcctt
gatgatcgtggacacatccggatttcagacctcggtttggccacagagatcccagaagga
cagagggttcgaggaagagttggaacagtcggctacatggcacctgaagttgtcaataat
gaaaagtatacgtttagtcccgattggtggggacttggctgtctgatctatgaaatgatt
cagggacattctccattcaaaaaatacaaagagaaagtcaaatgggaggaggtcgatcaa
agaatcaagaatgataccgaggagtattctgagaagttttcagaggatgccaaatctatc
tgcaggatgttactcaccaagaatccaagcaagcggctgggctgcaggggcgagggagcg
gctggggtgaagcagcaccccgtgttcaaggacatcaacttcaggaggctggaggcaaac
atgctggagccccctttctgtcctgatcctcatgccgtttactgtaaggacgtcctggat
atcgagcagttctcggtggtgaaagggatctacctggacaccgcagatgaagacttctat
gctcggtttgctaccgggtgtgtctccatcccctggcagaatgagatgatcgaatctggg
tgtttcaaagacatcaacaaaagtgaaagtgaggaagctttgccattagatctagacaag
aacatacataccccggtttccagaccaaacagaggcttcttctatagactcttcagaaga
gggggctgcctgaccatggtccccagtgagaaggaagtggaacccaagcaatgctga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (50)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (48)   
DNA sequence (88)   
   RefSeq(nuc) (52)   
   GenBank (18)   
   EMBL (18)   
3D Structure (1)   
   PDB (1)   
Protein domain (6)   
   Pfam (6)   
All databases (169)   

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